Premature ovarian failure is also known as primary ovarian insufficiency is a loss of normal function of the ovaries before age 40. Due to failure of the ovaries, the hormone estrogen is not released in amounts considered to be normal and therefore there is an irregularity in the release of eggs. This eventually and obviously leads to infertility.
Premature ovarian failure is sometimes referred to as premature menopause, but the two conditions aren’t the same. Women with premature ovarian failure can have irregular or occasional periods for years and might even become pregnant. Women with premature menopause stop having periods and can’t become pregnant. Even the signs and symptoms of premature ovarian failure are similar to those of going through menopause and are typical of estrogen deficiency.
However, a new therapy with Platelet-rich Plasma (PRP) can turn back the fertility clock for women who have experienced early menopause.
The Deccan Chronicle reported that a hospital in India has introduced Platelet-rich Plasma (PRP), a recent technique that can enable a woman to have babies even after menopause or with conditions like congenital ovarian failure.
In multiple studies, PRP has been shown to be effective and without any serious side effects in the areas of orthopedics, sports medicine, wound care, dental surgery, ophthalmology and in many cosmetic procedures.
PRP is isolated from a small sample of blood (about 10-20ml) taken from the patient, and centrifuged in a specialised tube. The PRP is a non-viscous fluid, which flows easily into the tissues and can be administered with a small-bore needle, increasing the comfort of the procedure. Once in the tissues, the PRP releases active growth factors which attract and activate pluripotent stem cells in the area of injection, stimulating neoangiogenesis, fibroblast growth, glandular proliferation and new neuronal growth, resulting in rejuvenation and even enhancement of damaged or undamaged tissue. PRP is completely autologous, so as yet there are no known contraindications to the treatment.
There are two types of treatment with PRP.
PRP in endometrium: This treatment is recommended for women with persistent thin lining < 6 mm in previous IVF or FET cycles, moderate-to-severe Asherman’s syndrome, and severe oligomenorrhea.
PRP in ovaries: This is recommended for women with primary or secondary amenorrhea for at least three months and infertile women more than 35 years of age having low ovarian reserve and low anti-mullerian hormone levels.
PRP is different from IVF: IVF is a procedure where an egg and a sperm is fertilised outside the womb and inserted back into the uterus. But in PRP, there’s no egg at all, a technique is used to produce and stimulate the egg.
Anecdotal evidence from patients suggests this procedure can be helpful for USI, reduced sensation, decreased arousal, anorgasmia, vaginal dryness, reduced sexual desire, dyspareunia, lichen sclerosis and fissures post-episiotomy.
A Greek lawyer (40) is expecting twins after experimental treatment with PRP. doctors initially said that she was a ‘lost cause’. But when she learned about the new technique, which claims to rejuvenate the reproductive organs by injecting blood plasma into the ovaries and womb, she decided to go for it. She says she conceived just nine days after receiving the injection and is now fourteen weeks pregnant with twins.
While this procedure is still in its infancy, results look very promising. Because the PRP is autologous – using the body’s own healing system with almost no serious side effects – it seems inherently safer.